Combinational approach using solid dispersion and semi-solid matrix technology to enhance in vitro dissolution of telmisartan

combinational approach using solid dispersion and semi-solid matrix technology to enhance in vitro dissolution of telmisartan

the present investigation was focused to formulate semi-solid capsules (sscs) of hydrophobic drug telmisartan (tlms) by encapsulating semi-solid matrix of its solid dispersion (sd) in hpmc capsules. the combinational approach was used to reduce the lag time in drug release and improvise its dissolution. sds of tlms was prepared using hot fusion method by varying the combinations of pluronic-f68...

Solid Dispersion- an Approach to Enhance the Dissolution Rate of Aceclofenac by Using 3 Factorial Design

Aceclofenac is an analgesic and anti-inflammatory agent used in the management of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. The objective of the present work was to investigate the effect of different types of carriers such as polyvinyl pyrrolidone (PVP), polyethylene glycol (PEG) 6000 and sodium lauryl sulphate (SLS) as solubilizer on in vitro dissolution of aceclofenac....

Solid Dispersion–an Approach to Enhance the Dissolution Rate of Amlodipine

Solid dispersion refers to the dispersion of one or more active ingredients in an inert carrier in a solid state, frequently prepared by the melting method, solvent method, or fusion solvent method. The oral bioavailability of poorly water soluble drug remains as the most challenging aspects of drug development. Solid dispersion approach is to reduce particle size, therefore increases the disso...

Formulation And Characterization Of Telmisartan Using Solid Dispersion Techniques

Telmisartan (TLM) is an angiotensin II receptor antagonist used in the treatment of hypertension. According to BCS (biopharmaceutical classification system) Telmisartan belongs to class II drug, and it is practically insoluble in water and it shows low dissolution profile and poor absorption. The present study is to improve the solubility of Telmisartan by solid dispersion techniques using vari...

dissolution rate enhancement of irbesartan using solid dispersion with pegs

Solid Dispersion Approach Improving Dissolution Rate of Stiripentol: a Novel Antiepileptic Drug

Some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. Stiripentol (STP) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. It has poor aqueous solubilityand its solubility has to be enhanced accordingly. Polyethyleneglycol 6000 (PEG-6000) iscommonly utilized as a hydrophilic...